WebThe therapeutic index (ratio of the minimum toxic concentration to the median effective concentration) helps determine the efficacy and safety of a drug. Increasing the dose of … WebAnswer: Drug B Explanation: Drug A : TD50 = 25 µg/ml ED50 = 21 µg/ml Drug B : T …. The therapeutic index of a drug is the ratio between the dose that is toxic in 50% of …

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Web4 mrt. 2024 · It has been considered that NTIDs generally have the fol- lowing characteristics [19, 20]: & Steep drug dose–response relationshipfor bothsafetyand efficacy within the usual dosing range or narrow span between effective drug concentrations and concentrations associated with serious adverse drug reactions. Web23 sep. 2024 · Some drugs are metabolized extensively by the liver and do not reach the general circulation (first-pass effect) C. All the drugs are stable at the low pH of the stomach. D. Rectal administration is the best way to give irritating drugs. E. Ingesting drugs with food always enhances drug absorption. 5. plumer in stourport

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Web20 nov. 2024 · Therapeutic index 1. THERAPEUTIC INDEX 2. A ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective. The ratio between the dosage of a drug that causes a lethal effect and the dosage that causes a therapeutic effect. The larger the therapeutic index (TI), the … http://www.pharmacologyeducation.org/pharmacology/pharmacodynamics WebWhen the metabolizing enzyme is inhibited, less of the drug will be metabolized by it in the epithelial cells. [13] This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity. plumeria plant seed pods