Hif2 antisense
Web3 de jun. de 2011 · These strategies include small-molecule therapeutics and antisense inhibitors, which interfere with HIF-1 synthesis, stability or transactivation, hypoxia-responsive viral vectors and hypoxia ... Web15 de set. de 2004 · Abstract. A natural antisense transcript (aHIF), which sequence is strictly complementary to the 3′ untranslated region (3′UTR) of HIF-1α mRNA, has been identified in human and shown to be overexpressed in renal carcinomas. We searched for aHIF in different rodent tissues.
Hif2 antisense
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Web2 de abr. de 2007 · Erythropoiesis is critically dependent on erythropoietin (EPO), a glycoprotein hormone that is regulated by hypoxia-inducible factor (HIF). Hepatocytes are the primary source of extrarenal EPO in the adult and express HIF-1 and HIF-2, whose roles in the hypoxic induction of EPO remain controversial. In order to define the role of HIF-1 … WebNormal adult rodents in which global HIF1 or HIF2 was inhibited by inducible gene deletion or pharmacological inhibition (antisense oligonucleotides (ASO) and small molecule …
Web11 de abr. de 2024 · Autotaxin (ATX), the key enzyme that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), is involved in tumorigenesis through the ATX-LPA axis and is regarded as a valuable target in tumor therapy. Hypoxia is a major feature of solid tumors and contributes to tumor development with striking alterations in the gene …
Web12 de dez. de 2024 · A small molecule HIF2 inhibitor (PT2567) significantly attenuated early events (monocyte recruitment and vascular cell proliferation) in rats exposed to 4 days of … Web7 de jul. de 2014 · We concluded that hif2-alpha is a key factor required for hepatic outgrowth and regulates leg1 expression in zebrafish embryos. ... The samples were …
Web12 de set. de 2024 · 通过诱导基因缺失或药理学抑制（反义寡核苷酸 (aso) 和小分子抑制剂）抑制整体 hif1 或 hif2 的正常成年啮齿动物暴露于短期（4 天）或慢性（4-5 周）缺氧。进行了血液动力学研究，对动物实施安乐死，并获得肺和心脏用于病理学和转录组学分析。
Web15 de jun. de 2024 · The negative strand of this locus produces multiple antisense noncoding transcripts in response to hypoxia; the highest expressed is HIF1-AS2 ( Mineo … chrzan thermomixWeb10 de out. de 2005 · To determine at what level Nox4 impacts HIF activity, we examined HIF2-α mRNA levels by quantitative RT-PCR (Figure 3) and were surprised to find that … describe the stages of meiotic cell divisionWeb2 de set. de 2024 · Normal adult rodents in which global HIF1 or 2 was inhibited by inducible gene deletion or pharmacological inhibition (antisense oligonucleotides-ASO and small molecule inhibitors) were exposed to short-term (4 days) or chronic (4–5 weeks) ... A small molecule HIF2 inhibitor (PT2567) significantly attenuated early events ... chs 12695 county 48 park rapids mnWeb20 de ago. de 2024 · 2.1. Plasmid Constructs. Human full-length GPT2 cDNA was amplified by PCR and cloned into p3 × FLAG-CMV-7 or pLV-HA-EGFP vector. DNA oligonucleotides containing wildtype (WT) or mutant GPT2 HRE (Supplementary Table S1) were annealed and ligated into MluI/BglII-linearized pGL2-promoter vector (Promega, Madison, WI, … describe the stages of product designTo investigate the contributions of HIF-1α in regulating glycolysis of cancer cells under hypoxia, we evaluated the dynamics of HIF-1α protein and its target genes related to glucose metabolism, including GLUT1, HKII, LDHA, and PDK15, following prolonged hypoxia. HIF-1α protein peaked at 4 h after the MDA … Ver mais Many of the lncRNAs exert their molecular functions by interacting with proteins17,31. To screen for HIFAL interacting proteins, we employed RNA … Ver mais Since we showed that HIFAL was mainly upregulated in the nucleus under hypoxia and could bind with PKM2 and PHD3, we hypothesized that HIFAL assisted nuclear translocation of the PKM2/PHD3 complex under hypoxic … Ver mais The above data revealed a central regulatory role of HIFAL lncRNA in HIF-1α-driven transcription and anaerobic glycolysis. To further … Ver mais Given that HIFAL expression was induced by hypoxia, we sought to determine whether HIFAL transcription was regulated by HIF-1α. Similar to other HIF-1α target genes (Fig. 1a), … Ver mais chs18a120as732Web16 de abr. de 2015 · Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol 2012; 32 : … chs 11 power steering fluidWeb2 de set. de 2024 · Summary: Activation of HIF2 by hypoxia initiates vascular cell proliferation and recruitment of inflammatory cells at early stages of PH development … chs18ss91038824h