WebSep 1, 2024 · Yevgeny Brudno, PhD, and his group at the North Carolina State University recently designed a bioinstructive scaffolds for rapid manufacture of CAR-T cells in vivo (Agarwalla et al., 2024). ... CAR-T cells were able to migrate efficiently out of the scaffold. A major concern using implantable technology for genetic engineering is transduction ... WebBioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells. P Agarwalla, EA Ogunnaike, S Ahn, KA Froehlich, A Jansson, FS Ligler, ... Nature biotechnology 40 (8), 1250-1258, 2024. 23: 2024: Clickable, acid labile immunosuppressive prodrugs for in vivo targeting.
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WebDec 16, 2024 · The scaffold implant could stimulate MSCs to release TRAIL antitumor protein for shrinking the volume of glioblastoma (GBM) xenograft and inhibiting its recurrence. 125 Besides cell delivery, the... WebAug 1, 2024 · Besides LNP-mediated strategies, implantable bioinstructive scaffolds have been developed, which can generate CAR-T cells in vivo and, hence, circumvent … east shore properties portsmouth ri
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WebFrances S. Ligler's 359 research works with 15,647 citations and 13,922 reads, including: Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells WebAgarwalla P, Ogunnaike EA, Ahn S, Froehlich KA, Jansson A, Ligler FS, Dotti G, Brudno Y, Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells. Nature biotechnology, 40(8), pp.1250-1258 (2024). Pandit S, Palvai S, Massaro NP, Pierce JG, Brudno Y. Tissue-reactive drugs enable materials-free local depots. WebMar 24, 2024 · These implantable scaffolds incorporate viruses and signaling factors in order to quickly and efficiently produce immunotherapeutic CAR-T cells. cumberland farms mohawk ave scotia ny